- Associate Director, Research Geriatric Research Education and Clinical Center
- Research Professor
As an investigator at the VA Puget Sound Health Care System, Dr. Kraemer’s research explores how protein aggregation contributes to neurodegenerative diseases. Dr. Kraemer has developed animal models of the TDP-43 pathology seen in ALS and the tau pathology seen in Alzheimer’s Disease and related dementias using both transgenic mice and transgenic C. elegans. Dr. Kraemer’s current work focuses on dissecting the genetic requirements for tau mediated neurodegeneration in these models. The approach taken is to use the experimental advantages of C. elegans to identify genes involved in tauopathy and validate finding in mouse models of disease. As new genes are identified that participate in tau and TDP-43 neurotoxicity, potential strategies for preventing neurodegeneration can be tested with the ultimate goal of developing effective therapies for neurodegenerative disease.