In new work published in the journal PLoS Genetics, UW HALO faculty member Dr. Daniel Promislow, BMHA (Genetic Approaches to Aging T32) trainee Kelly Jin, and colleagues at the Buck Institute describe the effects of dietary restriction on lifespan and the metabolome for dozens of genetically distinct strains of fruit fly. Their findings point to important, genetically-determined differences in the metabolic response to dietary restriction, some of which contribute to the effect of this diet on longevity. This work has implications for understanding why different genotypes respond differently to dietary restriction, and perhaps other longevity interventions, and may pave the way for predictive markers to help determine which individuals are likely to benefit – or be harmed – from such interventions in the future.
Read the press release here: https://newsroom.uw.edu/news/dissecting-fruit-flies-response-life-extension-diet
Read the full manuscript here: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008835