Scientific Press
Dog Aging Project featured in Discover Magazine
Tags: Scientific Press,
A story about the Dog Aging Project entitled “The Drug That Could One Day Help People — and Dogs — Live Longer” was published in the popular science magazine Discover. The article covers the upcoming Trial of Rapamycin in Aging Dogs (TRIAD) clinical trial. Low doses of rapamycin have been shown to extend lifespan and […]
Dog Aging Project Featured in Nature
Tags: Dog aging project, Scientific Press,
HALo’s Dog Aging Project—which hopes to develop treatments to slow aging and provide dogs and cats with three to five or more years of additional healthy, youthful life—was featured in an October 29th Nature article “Pet dogs set to test anti-ageing drug”. Low doses of rapamycin have been shown to safely slow aging and extend the period of […]
Treatments to rejuvenate the aging heart?
Tags: Heart failure, Scientific Press,
Caloric restriction is an anti-aging strategy that has been shown to extend lifespan and improve age-related diseases in animal models including non-human primates. Rapamycin, an FDA approved immune-suppressant drug, shares some similar anti-aging effects as caloric restriction. However, most studies of the anti-aging effects of caloric restriction or Rapamycin have been long-term studies in which […]
Curing a Childhood Syndrome? Kaeberlein Lab discovers possible drug for Leigh syndrome.
Tags: Leigh syndrome, Scientific Press,
While investigating the role of rapamycin (an FDA-approved immune-suppressant drug) in aging of yeast, fruit flies and C. elegans, researchers in Matt Kaeberlein’s lab also discovered something else. The drug can extend lifespan and alleviate neurological symptoms in a mouse model of mitochondrial disease. Mitochondria are a cells’ power generators, and mitochondrial dysfunction can lead […]
Improving muscle function: Effects of age may be more reversible than previously thought
Tags: Muscle function, Scientific Press,
The loss of skeletal muscle function is a leading cause of frailty and loss of independence in the elderly, which comes along with significant healthcare costs. Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle, but currently there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. David Marcinek’s lab […]
Anti-oxidant compound protects against heart failure in mice
Tags: Heart failure, Scientific Press,
A recent study in the Rabinovitch Lab has shown that an anti-oxidant compound, called SS-31, effectively protects against heart failure in mice, demonstrating a potential therapeutic value for human heart diseases. The study, Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides, was published in the September 2013 issue of Circulation: […]
Drugs to slow aging are a matter of when, not if
Tags: mTOR inhibition, Scientific Press,
Many experts in the biology of aging believe that pharmacological interventions to slow aging are a matter of ‘when’ rather than ‘if’. A review in the Journal Nature by UW Scientists, Simon Johnson, a graduate student in pathology; Peter Rabinovitch, professor of pathology; and Matt Kaeberlein, associate professor of pathology, argues that “slowing aging should increase both lifespan […]
