| Database | # of studies/subjects | Focus | Data Available | Data Details | Available to Public |
| Adult Changes in Thought (ACT) | 6,206 participants (as of March 2024) | Study of older adults to better understand factors that affect healthy aging and cognition over the life course | Genetics Biomarkers Neuro Physiological Medical Social Environmental Specimens | Genetic, Biomarker, or Other Specimen Data Activity Monitoring Device (Accelerometry) Data Neuroimaging Data Neuropathology Data Medical Record Abstraction Data Electronic Health Record & Utilization Data Historical Life Course & Social Determinants of Health Data ACT Study Visit Data | Data Query Tool Access upon request: Data Request Form |
| Dog Aging Project (DAP) | 52,599 canine participants (as of 2025) | Rigorous scientific research designed to define, explain, and ameliorate the effects of aging through a community of volunteers and researchers committed to helping dogs and humans live longer, healthier lives — together. | Demographics Physiological Environmental Social Nutrition Medical | Health and Life Experience Survey (HLES): Dog Demographics Physical Activity Environment Behavior Diet Comp Diet Meds and Preventitves Health Status Owner Demographics | Public: DAP GitHub public repository Curated data: access instructions |
| database of Genotypes and Phenotypes (dbGaP) | 3,450 individual studies | Public repository for individual-level phenotype, exposure, genotype, and sequence data, and the associations between them. | Varies by study selected: Genetics Phenotypes Molecular Data | Studies Phenotype Datasets Variables Analyses Molecular Datasets Documents | Data Query Tool Public: dbGaP Public Files Controlled data: Authorized Access Portal |
| Baltimore Longitudinal Study of Aging (BLSA) | 3,400+ participants | America’s longest-running scientific study of human aging. Genetics, lifestyle, and disease processes affect the rate of aging between and within all individuals. | Demographics Cognitive Physiological Environmental Social Nutrition Medical Imaging | Cohort Demographics CVD Cognition Nutrition Labs Body Imaging Physical Function Anthropometrics Glucose Blood Pressure Medications Body Composition Respiratory Health History Medical History Nerve function Senses Physical Performance Sleep Data Administrative Lab Tests Mitochondrial function Physical Activity Fatigue Health Metrics Self Rated Health Omics | Data Exploration Tool This repository is under review for potential modification in compliance with Administration directives. No public access, must apply through BLSA below or Alzheimer’s Disease Data Initiative (ADDI) Permissioned data or biospecimens: Authorized data access |
| National Health and Nutrition Examination Survey (NHANES) | ~5000 participants of all ages | NHANES is the only national health survey that includes health exams, laboratory tests, and dietary interviews for participants of all ages. | Genetics Neuro Physiological Medical Social Environmental Specimens Serum Plasma Urine | National Health and Nutrition Examination Survey: 1999–2022 Survey Content Brochure: Questionnaire components Postexamination follow-up questionnaire components Examination components Laboratory components By Approved Proposal only: DNA Specimens and Genetic Data Serum, Plasma, and Urine Specimens | Public: Limited; Data Query Tool Authorized Access: CDC Research Data Center |
| University of Michigan Health and Retirement Study (HRS) | ~20,000 participants | A longitudinal panel study that surveys a representative sample of approximately 20,000 people in America, supported by the National Institute on Aging (NIA U01AG009740) and the Social Security Administration. | Genetics Neuro Physiological Medical Social Environmental Specimens Insurance Cognitive | Public Data: Public Survey Data RAND Center for the Study of Aging HRS Products HRS Life History Data Resources Contributed Projects Restricted/Sensitive Data: Cognition Data Sensitive Biomarker and Health Data Restricted Data Administrative Linkages- Medicare and Social Security Genetic Data Biosamples | See Data Products, individual processes for Restricted/Sensitive Data |
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