- Assistant Professor of Lab Medicine and Pathology
Dr. Young joined the UW faculty in 2016 as an Assistant Professor in the Department of Lab Medicine and Pathology. Her research goal is to understand the molecular and biochemical mechanisms underlying age-related disorders, with a particular focus on neurodegenerative disorders. She has developed human stem cell models to further this line of research, as current animal models may not accurately recapitulate the phenotypes of brain aging. Her previous work on genome-editing showed that a familial AD mutation did not confer a loss of function phenotype and also published the first report of an AD-associated risk factor, SORL1, leading to a molecular phenotype in stem cell derived neurons from AD patients . Prior to her post-doctoral work, Dr. Young performed her graduate studies at UW where she was supported by the T32 Genetic Approaches to Aging Training Grant to study the mechanisms linking nutrient deprivation to autophagy [2,3].
1. Young JE et al. (2015) Elucidating molecular phenotypes caused by the SORL1 Alzheimer’s disease genetic risk factor using human induced pluripotent stem cells Cell Stem Cell 16:373-385 doi:10.1016/j.stem.2015.02.004
2. Young JE, Martinez RA, La Spada AR (2009) Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation J Biol Chem 284:2363-2373 doi:M806088200 [pii] 10.1074/jbc.M806088200
3. Young JE, La Spada AR (2009) Development of selective nutrient deprivation as a system to study autophagy induction and regulation in neurons Autophagy 5:555-557