Roles
Lindsey is a PhD candidate in the Bush lab. Her research involves developing novel crosslinking mass spectrometry methods and working with Rachel Klevit’s lab to apply these methods to the study of small heat shock proteins (sHSPs). sHSPs are chaperones that prevent aging associated protein aggregation. Using the reagent benzoylphenylalanine, she developed a targeted crosslinking method. She applied this crosslinking method to the sHSP HSPB5 and identified a network of novel HSPB5-HSPB5 interactions. Her goals are to continue developing the crosslinking method for improved quantification and to apply this method to additional systems to better understand HSPB5’s mechanism of action.
