UW Medicine

Michael MacCoss

Michael MacCoss


Professor of Genome Sciences

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Applications of mass spectrometry in the biology of aging

The focus of Dr. MacCoss’ laboratory is in the development and application of cutting edge mass spectrometry based technologies for the analysis of complex protein mixtures. His primary area of expertise is in protein biochemistry, nanoflow liquid chromatography, mass spectrometry instrumentation, and computational analysis of mass spectrometry data. He has 20+ years of mass spectrometry experience that bridges the fields of protein mass spectrometry, isotope ratio mass spectrometry, and quantitative mass spectrometry. He is a leader in the measurement of human amino acid and protein metabolism in vivo using stable isotope tracers. His laboratory has been actively applying these tools to important areas of aging biology including proteomic studies of caloric restriction and rapamycin, cardiac aging, and mitochondrial turnover with age. Dr. MacCoss has served on the Executive Committee for the UW Nathan Shock Center for 15 years and served as PI for the Shock Center Protein Phenotypes of Aging Core during this time.