UW Medicine

David Baker

David Baker

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Professor of Biochemistry
Adjunct Professor of Genome Sciences
Director, Institute for Protein Design

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Innovation in protein design to target aging and age-related disease Dr. Baker has pioneered methods to predict and design the three-dimensional structures of proteins. He is the Henrietta and Aubrey Davis Endowed Professor in Biochemistry and an adjunct professor of Genome Sciences, Bioengineering, Chemical Engineering, Computer Science, and Physics. He serves as the Director of […]

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Annabel Beichman

Annabel Beichman

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Post-doctoral Fellow

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Dr. Beichman is a postdoc in Dr. Kelley Harris’ Lab at UW Genome Sciences. Her research uses genomics to learn about mutation and demographic history in wild mammals that have experienced extreme demographic events or remarkable evolutionary transitions, including sea otters, bears, and whales. She received her Ph.D. from the University of California, Los Angeles […]

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Maitreya Dunham

Maitreya Dunham

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Professor of Genome Sciences

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Aneuploidy, evolution, and aging. Dr. Dunham develops and applies genomic tools to study genome evolution and genetic variation in yeast and humans. She has a special interest in how gene and chromosome copy number variation contributes to adaptation, the mechanisms by which such variation arises, and the relationship between aneuploidy and aging.  They utilize the budding […]

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Kelley Harris

Kelley Harris

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Assistant Professor of Genome Sciences

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Dr. Harris uses population genetic theory and high-throughput biological sequence analysis to study recent evolutionary history in humans and other species. One are of particular interest is the evolution of mutagenesis the forces that control DNA replication fidelity, the mutational breakdown of established traits, and the ultimate origin of new traits. Although DNA is replicated and […]

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Kathryn Jewett

Kathryn Jewett

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Dr. Kathryn A. Jewett, Ph.D. received her undergraduate and graduate degrees in Neuroscience from Washington State University. Her graduate work with Dr. James M. Krueger involved looking at the effects of electrical and chemical stimulation on cultured neural networks, correlating features between whole animal brain sleep/wake states and dissociated in vitro neural networks. After graduation […]

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Matt Kaeberlein

Matt Kaeberlein

Titles

Director, Healthy Aging and Longevity Research Institute
Director, Biological Mechanisms of Healthy Aging Training Program
Co-Director, UW Nathan Shock Center of Excellence in the Basic Biology of Aging
Co-Director, Dog Aging Project
Professor of Pathology
Adjunct Professor of Genome Sciences
Adjunct Professor of Oral Health Sciences

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Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the […]

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Mary-Claire King

Mary-Claire King

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Professor of Genome Sciences
Professor of Medical Genetics

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Aging factors in complex heritable conditions. Dr. King’s group uses next generation sequencing approaches to identify genes responsible for complex human conditions. Since the 1970s, her group has exploited approaches from genetics, then molecular biology, then genomics to discover and characterize genes for inherited disease. There are four areas of her work that offer insights […]

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Su-In Lee

Su-In Lee

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Associate Professor, Paul G. Allen School of Computer Science & Engineering
Associate Professor, Genome Sciences

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Understanding aging through explainable machine learning The Lee lab seeks to develop explainable AI for life sciences.  Explainable in this context means understanding which features drive the prediction.  The Lee lab has been collaborating with the Kaeberlein lab to develop and apply machine learning to aging biology, with the initial goal of using noisy human […]

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Michael MacCoss

Michael MacCoss

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Professor of Genome Sciences

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Applications of mass spectrometry in the biology of aging The focus of Dr. MacCoss’ laboratory is in the development and application of cutting edge mass spectrometry based technologies for the analysis of complex protein mixtures. His primary area of expertise is in protein biochemistry, nanoflow liquid chromatography, mass spectrometry instrumentation, and computational analysis of mass […]

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George Martin

George Martin

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Emeritus Professor of Lab Medicine and Pathology
Emeritus Professor of Genome Sciences

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Dr. Martin has led a long and productive career at the University of Washington, where he received his BS and MD degrees and has been a member of its faculty since 1957. He worked as a surgical pathologist and cytogeneticist in the UW Department of Pathology since 1957, and he served as the founding director […]

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Leo Pallanck

Leo Pallanck

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Professor of Genome Sciences

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Mitochondrial quality control in aging. Much of Dr. Pallanck’s current work stems from his studies of Drosophila homologs of the Parkinson’s disease-related genes parkin and PINK1. His work on Parkin and PINK1 led to his hypothesis that these factors promote the degradation of damaged mitochondria through mitophagy, a mitochondrial-selective form of autophagy. Work in many […]

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Christine Queitsch

Christine Queitsch

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Professor of Genome Sciences

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Gene regulation and heritable phenotypic variation in aging The Queitsch lab focuses on two related fields: the genetic architecture of complex traits and the role of gene regulation and protein folding in generating heritable phenotypic variation – including phenotypes of aging. We advance complex trait genetics by ascertaining uncharacterized sequence variation and by resolving the […]

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Hannele Ruohola-Baker

Hannele Ruohola-Baker

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Professor of Biochemistry
Adjunct Professor of Biology
Adjunct Professor of Genome Sciences

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Adult stem cell aging Dr. Ruohola-Baker’s laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity. During the recent years the laboratory has shown that microRNAs and the HIF pathway play key roles in regulating adult and embryonic stem cell self-renewal in model organisms as well as […]

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Paul Valdmanis

Paul Valdmanis

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Assistant Professor, Medical Genetics
Adjunct Assistant Professor, Genome Sciences
Adjunct Assistant Professor, Lab Medicine and Pathology

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Age-associated changes in synaptic non-coding RNAs Dr. Valdmanis joined the UW as an Assistant Professor in 2017.  His research has historically been focused on identification of mutations in genes that are responsible for neurodegenerative diseases such as ALS.  Recently, he has begun studying the role of non-coding RNAs in synaptic aging.  He has hypothesized that […]

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Judit Villen

Judit Villen

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Associate Professor of Genome Sciences

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Dr. Villen is an Associate Professor in the Department of Genome Sciences. She earned her PhD in Chemistry from the University of Barcelona. During her postdoc at Harvard Medical School she was involved in several technology developments that enabled the robust characterization of thousands of phosphorylation sites: from biochemical methods to mass spectrometry acquisition strategies […]

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