UW Medicine

Paul Valdmanis

Paul Valdmanis


Assistant Professor, Medical Genetics
Adjunct Assistant Professor, Genome Sciences
Adjunct Assistant Professor, Lab Medicine and Pathology

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Age-associated changes in synaptic non-coding RNAs

Dr. Valdmanis joined the UW as an Assistant Professor in 2017.  His research has historically been focused on identification of mutations in genes that are responsible for neurodegenerative diseases such as ALS.  Recently, he has begun studying the role of non-coding RNAs in synaptic aging.  He has hypothesized that progressive changes in alternative splicing patterns in an aging population alter synaptic transcripts that affect neuronal function.  Moreover, he is interested in testing the idea that we can intervene in some of these processes to preserve healthspan of individuals.