UW Medicine

Paul Valdmanis

Paul Valdmanis


Associate Professor, Medical Genetics
Adjunct Associate Professor, Genome Sciences
Adjunct Associate Professor, Lab Medicine and Pathology

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Age-associated changes in synaptic non-coding RNAs

Dr. Valdmanis joined the University of Washington as an Assistant Professor in 2017. His lab studies genetic risk factors for neurodegenerative diseases such as Alzheimer’s disease and Amyotrophic Lateral Sclerosis and gene therapy methods for therapeutic intervention. Through a series of studies focusing on long-read sequencing of the genome and transcriptome, his group has identified tandem repeats that expand in individuals and complex alternative splicing patterns that accumulate as a function of age, especially at the synapse. He is studying the effect that these repeat expansions and alternative splicing changes have on appropriate brain function throughout the course of human aging.