Genome replication and its role in aging Dr. Bedalov is an Associate Member in the Clinical Research Division at the Fred Hutchinson Cancer Research Center. Dr. Bedalov is a bone marrow transplant specialist who treats people for blood disorders, leukemia, lymphoma, multiple myeloma and myelodysplastic syndrome. He runs an active research laboratory that uses S. […]
Role of DNA mutation in aging and cancer Dr. Bielas is an Associate Member in the Translational Research Program at the Fred Hutchinson Cancer Research Center, and an Affiliate Associate Professor in the UW Department of Lab Medicine and Pathology. He has a long-standing interest in the relationships between aging, mutagenesis, and cancer. His past […]
Dr. Harris uses population genetic theory and high-throughput biological sequence analysis to study recent evolutionary history in humans and other species. One are of particular interest is the evolution of mutagenesis the forces that control DNA replication fidelity, the mutational breakdown of established traits, and the ultimate origin of new traits. Although DNA is replicated and […]
Dr. Nicholas Lehrbach’s research focuses on discovering the cellular pathways that normally function to remove unwanted proteins, and how they become mis-regulated in disease. High levels of abnormal or damaged proteins is a cellular feature of aging, cancer, adult-onset neurodegenerative diseases, and many rare genetic disorders. Dr. Lehrbach and his team use C. elegans to […]
Dr. Severs is a postdoctoral fellow in the lab of Aakanksha Singhvi, in the Basic Sciences Department at Fred Hutch Cancer Center. She is interested in studying how glia communicate with neurons to impact behavior, and how this changes with age. Specifically, Dr. Severs is examining how sense-organ glia in the model organism Caenorhabditis elegans […]
Dr. Singhvi’s lab investigates the role of glia in neural function, aging and disease. Our nervous system has two major cell types, glia and neurons, in about equal numbers. Glia communicate with neurons to modulate neuron shape and function, and thereby neural circuit activity and animal behaviors. To define the molecular basis of neural aging, […]
Sarah Tomlin is a graduate student in the Molecular and Cellular Biology (MCB) Ph.D. program, conducting her thesis research in the Lehrbach Lab within the Basic Sciences Division at Fred Hutch. Her research utilizes genetics, biochemistry, and molecular biology techniques in the model organism C. elegans to investigate the fundamental mechanisms by which cells regulate protein degradation. […]
Dr. Yanagi is a postdoctoral fellow in Nicolas Lehrbach’s lab at Fred Hutchinson Cancer Center. Her research uses C. elegans genetics and reporter-based assays in combination with molecular biology and biochemistry to address how protein homeostasis is maintained as organisms age. Dr. Yanagi received her PhD in Neuroscience from Brown University. […]
