UW Medicine

Margaret M. Sedensky

Margaret M. Sedensky


Principal Investigator, Seattle Children’s Research Institute
Professor, Anesthesiology and Pain Medicine

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Research Interest

The Sedensky laboratory is using two model systems to understand multiple ramifications of mitochondrial dysfunction. Lifespan and neurodegeneration are two areas under active investigation. A long standing focus is understanding how mitochondrial function controls behavior in the volatile anesthetics.

Selected publications

Falk MJ, Kayser EB, Morgan PG, Sedensky MM. (2006). Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans. Curr Biol, 16: 1641-45.

Singaram VK, Somerlot BH, Falk SA, Falk MJ, Sedensky MM, Morgan PG. (2011). Optical reversal of halothane-induced immobility in C. elegans. Curr Biol. 21: 2070-2076.

Quintana A*, Morgan PG*, Kruse SE, Palmiter RD, Sedensky MM. (2012). Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I. PLoS One, 7: e42904. (*, co-first authors).

Suthammarak W, Somerlot BH, Opheim E, Sedensky M, Morgan PG. (2013). Novel Interactions between Mitochondrial Superoxide Dismutases and the Electron Transport Chain. Aging Cell,12 (6): 1132-40.

Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M. (2013).  mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science, 342 (6165): 1524-8.