Proteostasis and aging The accumulation of structurally aberrant proteins underlies over 30 human disorders. These include such devastating diseases as Alzheimer’s, Parkinson’s, Huntington’s, and ALS. Collectively, these disorders are called “protein aggregation” disorders because protein inclusions are usually observed in affected cells. Some protein aggregation diseases result from toxic accumulation in the cytoplasm and extracellular […]
Understanding of molecular recognition, and interactions that play important roles in aging and disease Dr. Klevit is the Edmond H. Fischer/WRF Endowed Chair in Biochemistry, an Adjunct Professor of Pharmacology, and Adjunct Professor of Chemistry. Current research in Dr. Klevit’s laboratory is directed towards an understanding of fundamental molecular recognition events involved in the process […]
